| Code | EK0462 |
| Brand | Boster |
| Title | Mouse MMP-3 PicoKine"! ELISA Kit |
| Description | Mouse MMP-3 PicoKine”! ELISA Kit |
| Size | 1 x 96T |
| alternative_name | Stromelysin-1 |
| Scheda prodotto | www.bosterbio.com/datasheet.php?sku=EK0462 |
| general_information | Matrix metalloproteinase-3(MMP-3) also called stromelysin or transin, is a proteoglycanase closely related to collagenase(MMP1) with a wide range of substrate specificities. The complete primary structure for human MMP-3, which has 477 residues including a 17-residue signal peptide. MMP-3 and collagenase are 54% identical in sequence, suggesting a common origin for the evolution of the two proteinases. MMP-3 and collagenase expression are coordinately modulated in synovial fibroblast cultures. MMP-3 is a secreted metalloprotease produced predominantly by connective tissue cells. Together with other metalloproteases, it can synergistically degrade the major components of the extracellular matrix. It is capable of degrading proteoglycan, fibronectin, laminin, and type IV collagen, but not interstitial type I collagen. MMP-3 genotype may be an important determinant of vascular remodeling and age-related arterial stiffening, with the heterozygote having the optimal balance between matrix accumulation and deposition. |
| protein_id | P28862 |
| range_detection | 156pg/ml-10,000pg/ml |
| sensitivity | <10pg/ml |
| storage | Store at 4Ú C for 6 months, at -20Ú C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.) |
| Detection method | ELISA |
| Sample Type | cell culture supernates, serum and plasma (heparin). |
| Target species | Mouse |
| Assay type | complete kit |
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