| Code | EK0830 |
| Brand | Boster |
| Title | Mouse RANK PicoKine"! ELISA Kit |
| Description | Mouse RANK PicoKine”! ELISA Kit |
| Size | 1 x 96T |
| alternative_name | Tumor necrosis factor receptor superfamily member 11A |
| Scheda prodotto | www.bosterbio.com/datasheet.php?sku=EK0830 |
| general_information | Receptor Activator of Nuclear Factor kappa B(RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is a recently described TNF receptor family member, and its ligand, RANKL, promote survival of dendritic cells and differentiation of osteoclasts. RANK contains 383 amino acids in its intracellular domain(residues 234-616), which contain three putative TRAF-binding domains(termed I, II, and III). RANK interacts with various TRAFs through distinct motifs and activates NF-kappaB via a novel TRAF6 interaction motif, which then activates NIK, thus leading to NF-kappaB activation, whereas RANK most likely activates JNK through a TRAF2-interacting region in RANK. |
| protein_id | O35305 |
| range_detection | 62.5pg/ml-4000pg/ml |
| sensitivity | <2pg/ml |
| storage | Store at 4Ú C for 6 months, at -20Ú C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.) |
| Detection method | ELISA |
| Sample Type | cell culture supernates and serum. |
| Target species | Mouse |
| Assay type | complete kit |
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