Flat Preloader Icon Attendere..
CodeEK1118
BrandBoster
TitleHuman A2M/Alpha2-Macroglobulin PicoKine"! ELISA Kit
DescriptionHuman A2M/Alpha2-Macroglobulin PicoKine”! ELISA Kit
Size1 x 96T
alternative_nameAlpha-2-macroglobulin
Scheda prodottowww.bosterbio.com/datasheet.php?sku=EK1118
general_informationAlpha-2-macroglobulin, also known as A2M or CPAMD5 is a large plasma protein found in the blood. This gene is mapped to 12p13.31. Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease(AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. This gene is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates(activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
protein_idP01023
range_detection625pg/ml-40,000pg/ml
sensitivity<20pg/ml
storageStore at 4Ú C for 6 months, at -20Ú C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
Detection methodELISA
Sample Typecell culture supernates, cell lysates, serum and plasma (heparin, EDTA).
Target speciesHu
Assay typecomplete kit