| Code | EK0972 |
| Brand | Boster |
| Title | Human TNFRSF16/NGFR PicoKine"! ELISA Kit |
| Description | Human TNFRSF16/NGFR PicoKine”! ELISA Kit |
| Size | 1 x 96T |
| alternative_name | Tumor necrosis factor receptor superfamily member 16 |
| Scheda prodotto | www.bosterbio.com/datasheet.php?sku=EK0972 |
| general_information | Nerve growth factor receptor (NGFR) is also referred to as p75(NTR) because of its ability to bind at low affinity not only to NGF, but also other neurotrophins including brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5. The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias. The neurotrophin receptor p75(NTR), a tumor necrosis factor receptor superfamily member expressed in hepatic stellate cells after fibrotic and cirrhotic liver injury in humans, is a regulator of liver repair. In mice, depletion of p75(NTR) exacerbated liver pathology and inhibited hepatocyte proliferation in vivo. In addition, it is showed that neurotrophins activate p75(NTR) to induce apoptosis through the induction of the sphingomyelin (SM) cycle and increased production of ceramide. Overexpression of p75(NTR) is also found to activate the SM pathway. |
| protein_id | P08138 |
| range_detection | 62.5pg/ml-4000pg/ml |
| sensitivity | <10pg/ml |
| storage | Store at 4Ú C for 6 months, at -20Ú C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.) |
| Detection method | ELISA |
| Sample Type | cell culture supernates, serum and plasma(heparin, EDTA, citrate). |
| Target species | Hu |
| Assay type | complete kit |
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