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CodeEK1449
BrandBoster
TitleHuman PD-L1/B7-H1 PicoKine"! ELISA Kit
DescriptionHuman PD-L1/B7-H1 PicoKine”! ELISA Kit
Size1 x 96T
alternative_nameProgrammed cell death 1 ligand 1
Scheda prodottowww.bosterbio.com/datasheet.php?sku=EK1449
general_informationProgrammed death-ligand 1 (PD-L1), also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1), is a protein that in humans is encoded by the CD274 gene. PD-L1 is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. Normally the immune system reacts to foreign antigens where there is some accumulation in the lymph nodes or spleen which triggers a proliferation of antigen-specific CD8+ T cell. The formation of PD-1 receptor / PD-L1 or B7.1 receptor /PD-L1 ligand complex transmits an inhibitory signal which reduces the proliferation of these CD8+ T cells at the lymph nodes and supplementary to that PD-1 is also able to control the accumulation of foreign antigen specific T cells in the lymph nodes through apoptosis which is further mediated by a lower regulation of the gene Bcl-2.
protein_idQ9NZQ7
range_detection62.5pg/ml-4000pg/ml
sensitivity<12pg/ml
storageStore at 4Ú C for 6 months, at -20Ú C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
Detection methodELISA
Sample Typecell culture supernates, cell lysates, serum and plasma (heparin, EDTA).
Target speciesHu
Assay typecomplete kit