| Code | EK1550 |
| Brand | Boster |
| Title | Mouse Meteorin-like/METRNL PicoKine"! ELISA Kit |
| Description | Mouse Meteorin-like/METRNL PicoKine”! ELISA Kit |
| Size | 1 x 96T |
| alternative_name | Meteorin-like protein |
| Scheda prodotto | www.bosterbio.com/datasheet.php?sku=EK1550 |
| general_information | METRNL (Meteorin-like) is a cytoplasmic 30 kDa (predicted) member of the meteorin family of proteins. It is expressed by neurons, and appears to function as a primer molecule that sets the stage for either cell differentiation or neurite outgrowth when it acts with Dclk1 and SerpinB1. In mice, exogenously elevated circulating Metrnl increased whole-body energy expenditure and improved glucose tolerance following diet-induced obesity. It also induced expression of antiinflammatory genes, leading to alternative activation of macrophages in adipose tissue and to browning of white fat depots. Metrnl did not appear to activate thermogenic genes directly, but it stimulated eosinophils and macrophages to enter adipose tissue and take their specific thermogenic actions. Blockade of cytokine signaling eliminated Metrnl-induced changes in gene expression required for alternative macrophage activation and blunted expression of beige fat thermogenic and beta-oxidation genes. It is concluded that METRNL is a hormone that influences energy expenditure and thermogenic programs in adipose tissue. |
| protein_id | Q8VE43 |
| range_detection | 62.5pg/ml-4000pg/ml |
| sensitivity | <12pg/ml |
| storage | Store at 4Ú C for 6 months, at -20Ú C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.) |
| Detection method | ELISA |
| Sample Type | cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
| Target species | Mouse |
| Assay type | complete kit |
Attendere..
