Code | FEK1414 |
Brand | Boster |
Title | Mouse CD5L / CT 2 PicoKine™ Fast ELISA Kit |
Description | Mouse CD5L / CT 2 PicoKine™ Fast ELISA Kit |
Size | 1 x 96T |
alternative_name | CD5 antigen-like |
concentration | N/A |
Scheda prodotto | LINK |
general_information | CD5 antigen-like, also known as Sp alpha and AIM, is a protein that in humans is encoded by the CD5L gene. It is mapped to 1q21-q23 by fluorescence in situ hybridization. It is found that Aim expression is induced in mouse macrophages in response to loading with highly oxidized low density lipoprotein (oxLDL), and that Aim is expressed in foam cells within atherosclerotic lesions. Both the expression of Aim in lesions and its induction by oxLDL require Lxr /Rxr heterodimers. Aim-null macrophages are highly susceptible to oxLDL-induced apoptosis in vitro and undergo accelerated apoptosis in atherosclerotic lesions in vivo. Double knockout of Aim and Ldlr reduce atherosclerotic lesions. Therefore, it is concluded that AIM expression protects macrophages from apoptosis within atherosclerotic lesions, promoting early lesion development. |
protein_id | Q9QWK4 |
range_detection | 156pg/ml-10,000pg/ml |
sensitivity | <10pg/ml |
storage | Store at 4Ú C for 6 months, at -20Ú C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.) |
Detection method | ELISA |
Sample Type | cell culture supernates, serum and plasma(heparin). |
Target species | mouse |
Target_ig | N/A |
Assay type | complete kit |