Flat Preloader Icon Attendere..
CodeM73000-1
BrandEpigentek
TitleVX-680 (MK-0457, Tozasertib)
DescriptionVX-680 (MK-0457, Tozasertib)
Size25 mg
Scheda prodottoLINK
formatN/A
hostN/A
id_area_ricerca34
notesMK 0457 is a potent pan-Aurora kinase inhibitor but favors Aurora A (Ki = 0.6 nM) over Aurora B (Ki = 18 nM) or Aurora C (Ki = 4.6 nM). It shows selectivity against a panel of more than 190 different protein kinases. MK 0457 effectively inhibits proliferation of several different cell lines of clear cell renal carcinoma (IC50s < 10 µM) and blocks the growth of tumors in a rodent model of cancer (80 mg/kg), inhibiting histone H3 phosphorylation and increasing apoptosis. By depleting Aurora activity, MK 0457 disrupts bipolar spindle formation during mitosis, arresting cell cycle progression at the G2/M phase.
research_areaEpigenetics
storagesee data sheet
ApplicationKinase inhibitor
Target speciesN/A
HostN/A