Annexin A1 Polyclonal Antibody

Code	PB9127
Brand	Boster
Title	Annexin A1 Polyclonal Antibody
Description	Annexin A1 Polyclonal Antibody
Size	100 ug
alternative_name	alpha catenin antibody\|alpha E catenin antibody\|Alpha E-catenin antibody\|alphaE catenin antibody\|Cadherin associated protein 102kDa antibody\|Cadherin associated protein antibody\|Cadherin-associated protein antibody\|CAP 102 antibody\|CAP102 antibody\|Catenin (cadherin associated protein) alpha 1 102kDa antibody\|Catenin (cadherin associated protein), alpha 1, 102kDa antibody\|Catenin alpha 1 antibody\|Catenin alpha-1 antibody\|CTNA1_HUMAN antibody\|CTNNA 1 antibody\|CTNNA1 antibody\|FLJ36832 antibody\|FLJ52416 antibody\|NY REN 13 antigen antibody\|OTTHUMP00000224141 antibody\|OTTHUMP00000224147 antibody\|Renal carcinoma antigen NY REN 13 antibody\|Renal carcinoma antigen NY-REN-13 antibody
clone	N/A
concentration	N/A
Scheda prodotto	LINK
format	Whole IgG
general_information	ANXA1, also known as lipocortin I or Annexin A1, is a protein that in humans is encoded by the ANXA1 gene. It is mapped to 9q21.13. ANXA1 belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. ANXA1 protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Lower peptide concentrations possibly found in inflammatory situations elicit Ca(2+) transients without fully activating the mitogen-activated protein kinase pathway. This causes a specific inhibition of the transendothelial migration of neutrophils and a desensitization of neutrophils toward a chemoattractant challenge. These findings identified ANXA1 peptides as novel, endogenous FPR ligands and established a mechanistic basis of ANXA1-mediated antiinflammatory effects.
host	Rabbit
immunogen	E.coli-derived human Annexin A1 recombinant protein (Position
isotype	IgG
Secondary antibodies	LINK
protein_id	P04083
purity	Affinity Purified
storage	At -20Ú C for one year. After reconstitution, at 4Ú C for one month. It can also be aliquotted and stored frozen at -20Ú C for a longer time. Avoid repeated freezing and thawing.
Application	WB,IHC
Target species	Hu, Ms, Rt
Host	Rabbit
Class	Polyclonal
Labeled	Unconjugated