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CodeA00543-2
BrandBoster
TitleAnti-Cyclin E1/CCNE1 Polyclonal Antibody
DescriptionAnti-Cyclin E1/CCNE1 Polyclonal Antibody
Size100ug
alternative_nameG1/S-specific cyclin-E1
cloneN/A
concentrationN/A
Scheda prodottoLINK
formatRabbit IgG
general_informationG1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene. It is mapped to 19q12. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.
hostRabbit
isotypeIgG
Secondary antibodiesLINK
protein_id_urlP24864
storageAt -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.
ApplicationWB,IHC-P,FCM,Direct ELISA
Target_ighuman, mouse, rat
HostRabbit
ClassPolyclonal
LabeledUnconjugated