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CodeA03671-4
BrandBoster
TitleAnti-DFFA/ICAD Polyclonal Antibody
DescriptionAnti-DFFA/ICAD Polyclonal Antibody
Size100ug
alternative_nameDFFA
cloneN/A
concentrationN/A
Scheda prodottoLINK
formatRabbit IgG
general_informationDNA fragmentation factor subunit alpha (DFFA), also known as Inhibitor of caspase-activated DNase (ICAD), is a protein that in humans is encoded by the DFFA gene. Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
hostRabbit
isotypeIgG
Secondary antibodiesLINK
protein_idO00273
storageAt -20Ú C for one year. After reconstitution, at 4Ú C for one month. It can also be aliquotted and stored frozen at -20Ú C for a longer time. Avoid repeated freezing and thawing.
ApplicationWB,FCM,Direct ELISA
Target_ighuman, rat
HostRabbit
ClassPolyclonal
LabeledUnconjugated