Cambinol - TEMA RICERCA

Code	M47000-1
Brand	Epigentek
Title	Cambinol
Description	Cambinol
Size	5 mg
Scheda prodotto	LINK
format	N/A
host	N/A
id_area_ricerca	34
notes	Cambinol is a cell-permeable β-naphthol compound that inhibits the NAD-dependent deacetylase activity of hSIRT1 and hSIRT2 (IC50 = 56 µM and 59 µM, respectively) in a substrate-, but not NAD-, competitive manner. It inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 µM) and exhibits no inhibition against class I and II HDACs. Cambinol-induced apoptosis in BCL6-expressing Burkitt lymphoma cell lines has been attributed to the hyperacetylation of BCL6 and p53. Shown to effectively inhibit xenografted Daudi Burkitt lymphoma growth in mice in vivo.
research_area	Epigenetics
storage	see data sheet
Application	HDAC inhibitor
Target species	N/A
Host	N/A