DKK4 Polyclonal Antibody

Code	A08464
Brand	Boster
Title	DKK4 Polyclonal Antibody
Description	DKK4 Polyclonal Antibody
Size	100 ug
alternative_name	Dickkopf-related protein 4
clone	N/A
concentration	N/A
Scheda prodotto	LINK
format	N/A
general_information	DKK4 is a membersof the Dickkopf family which are negative regulators of the growth-promoting Wnt / beta-catenin signaling pathway. By FISH, the DKK4 gene was mapped to chromosome 8p11.2-p11.1. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. The expression of DKK4 was significantly reduced in hepatocellular carcinomas (HCCs), particularly in HCCs that showed cytoplasmic beta- catenin accumulation. DKK4 expression was also reduced in HCC cell lines. Ectopic expression of DKK4 in 2 HCC cell lines reduced beta-catenin and cyclin D1 protein levels and attenuated beta-catenin activity in reporter gene assays.
host	Goat
immunogen	Synthetic peptide with sequence RQHARLRVCQKIEKL, corresponding to the C Terminus of the protein sequence.
isotype	N/A
protein_id	Dkk4
purity	Immunogen Affinity Purified
storage	At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.
Application	WB
Target species	Hu, Ms, Rt
Host	Goat
Class	Polyclonal
Labeled	Unconjugated