Code | FEK0644 |
Brand | Boster |
Title | Human CD105 PicoKine™ Fast ELISA Kit |
Description | Human CD105 PicoKine™ Fast ELISA Kit |
Size | 1 x 96T |
alternative_name | Endoglin |
concentration | N/A |
Scheda prodotto | LINK |
general_information | CD105, also called Endoglin, is a homodimeric membrane glycoprotein primarily associated with human vascular endothelium. It is also found on bone marrow proerythroblasts, activated monocytes, and lymphoblasts in childhood leukemia. Endoglin is a component of the transforming growth factor-beta(TGFB) receptor complex and binds TGFB1 with high affinity.1 CD105 gene is mapped to 9q34.1. The coding region of the gene contains 14 exons.2 The protein consists of a homodimer of 180 kDA with disulfide links. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. Furthermore, it also has a role in the balance of ALK1 and ALK5 signaling to regulate endothelial cell proliferation.3 Moreover, the elevated expression of endoglin in the surgically excised CNVMs suggested a persisting postmitotic activation in an advanced stage of neovascular tissue.4 The standard product used in this kit is extracellular part of recombinant human CD105, from E26 to G586. As a result of glycosylation, the molecular mass is 75-85KDa. |
protein_id | P17813 |
range_detection | 156pg/ml-10,000pg/ml |
sensitivity | <15pg/ml |
storage | Store at 4Ú C for 6 months, at -20Ú C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.) |
Detection method | ELISA |
Sample Type | cell culture supernates, serum and plasma(heparin). |
Target species | Hu |
Target_ig | N/A |
Assay type | complete kit |