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CodeFEK0830
BrandBoster
TitleMouse RANK / CD265 PicoKine™ Fast ELISA Kit
DescriptionMouse RANK / CD265 PicoKine™ Fast ELISA Kit
Size1 x 96T
alternative_nameTumor necrosis factor receptor superfamily member 11A
concentrationN/A
Scheda prodottoLINK
general_informationReceptor Activator of Nuclear Factor kappa B(RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is a recently described TNF receptor family member, and its ligand, RANKL, promote survival of dendritic cells and differentiation of osteoclasts. RANK contains 383 amino acids in its intracellular domain(residues 234-616), which contain three putative TRAF-binding domains(termed I, II, and III). RANK interacts with various TRAFs through distinct motifs and activates NF-kappaB via a novel TRAF6 interaction motif, which then activates NIK, thus leading to NF-kappaB activation, whereas RANK most likely activates JNK through a TRAF2-interacting region in RANK.
protein_idO35305
range_detection62.5pg/ml-4000pg/ml
sensitivity<2pg/ml
storageStore at 4Ú C for 6 months, at -20Ú C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
Detection methodELISA
Sample Typecell culture supernates, serum and plasma(heparin).
Target speciesMouse
Target_igN/A
Assay typecomplete kit