| Code | EK1436 |
| Brand | Boster |
| Title | Mouse TPOR/MPL PicoKine"! ELISA Kit |
| Description | Mouse TPOR/MPL PicoKine”! ELISA Kit |
| Size | 1 x 96T |
| alternative_name | Thrombopoietin receptor |
| Scheda prodotto | www.bosterbio.com/datasheet.php?sku=EK1436 |
| general_information | The thrombopoietin receptor (TPOR), also known as CD110, is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene. The human MPL gene is mapped to chromosome 1p34. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. |
| protein_id | Q08351 |
| range_detection | 156pg/ml-10000pg/ml |
| sensitivity | <15pg/ml |
| storage | Store at 4Ú C for 6 months, at -20Ú C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.) |
| Detection method | ELISA |
| Sample Type | cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
| Target species | Mouse |
| Assay type | complete kit |
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