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CodeEK1371
BrandBoster
TitleRat Hemojuvelin/RGM-C PicoKine"! ELISA Kit
DescriptionRat Hemojuvelin/RGM-C PicoKine”! ELISA Kit
Size1 x 96T
alternative_nameHemojuvelin
Scheda prodottowww.bosterbio.com/datasheet.php?sku=EK1371
general_informationHemojuvelin (HJV/RGMc/HFE2) is a membrane-bound and soluble protein in mammals. It is a member of the repulsive guidance molecule family of proteins. The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
protein_idQ8N7M5
range_detection62.5pg/ml-4000pg/ml
sensitivity<12pg/ml
storageStore at 4Ú C for 6 months, at -20Ú C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
Detection methodELISA
Sample Typecell culture supernates, cell lysates, serum and plasma (heparin, EDTA).
Target speciesRat
Assay typecomplete kit