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CodeM45001-1
BrandEpigentek
TitleSplitomicin
DescriptionSplitomicin
Size5 mg
Scheda prodottoLINK
formatN/A
hostN/A
id_area_ricerca34
notesSplitomicin is a cell-permeable lactone that acts as a selective inhibitor of NAD+ dependent histone deacetylase activity of Sir2 protein. It creates a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.
research_areaEpigenetics
storagesee data sheet
ApplicationHDAC inhibitor
Target speciesN/A
HostN/A